Manipulating cell cycle regulation in the mature cochlea
نویسندگان
چکیده
منابع مشابه
T-cell malignancies with mature phenotypes: altered cell cycle regulation by HLA class I molecules.
Soluble anti-HLA class I monoclonal antibodies (MoAbs) modulate normal T-lymphocyte proliferation induced via the CD3/Ti and the CD2 pathway, but do not induce proliferation of normal T lymphocytes in the absence of additional mitogenic stimuli. In this report, we show that anti-HLA class I MoAbs induce DNA synthesis in peripheral blood mononuclear cells from a patient with a CD4+CD8+T-prolymph...
متن کاملCell Cycle Regulation in Plants.
Cell division plays a crucial role during a11 phases of plant development. Continuing organogenesis and plastic growth responses to a changing environment require precise spatial, temporal, and developmental regulation of cell division activity in meristems. The molecular analysis of cell division and its regulation in plants lags far behind such studies in yeast and animals. Since the cell the...
متن کاملCardiomyocyte cell cycle regulation.
Although rapid progress is being made in many areas of molecular cardiology, issues pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic induction, and the pathways that regulate cardiomyocyte proliferation during embryonic and adult life remain unanswered. In the present study, we review approaches and studies that have shed some light on cardiomyocyte c...
متن کاملCell-cycle regulation.
Cell-division control affects many aspects of development. Caenorhabditis elegans cell-cycle genes have been identified over the past decade, including at least two distinct Cyclin-Dependent Kinases (CDKs), their cyclin partners, positive and negative regulators, and downstream targets. The balance between CDK activation and inactivation determines whether cells proceed through G1 into S phase,...
متن کاملE2F1 works as a cell cycle suppressor in mature neurons.
Neurons are highly differentiated cells that normally never enter a cell cycle; if they do, the result is usually death, not division. For example, cerebellar granule neurons in staggerer and lurcher mutant mice initiate a cell cycle-like process just before they die. E2F1 is a transcription factor that promotes cell cycle progression. Because E2F1 is also involved in apoptosis, we bred double ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hearing Research
سال: 2007
ISSN: 0378-5955
DOI: 10.1016/j.heares.2007.06.005